Posted by SLS on January 31, 2013, at 10:26:40
In reply to question on minocycline, posted by alchemy on January 30, 2013, at 16:43:56
> Scott,
> I have an apt tomorrow with my pdoc who basically said we have reached the end of the road. Have you found minocycline to help very much? What could I tell my dr to convince him?
> ThanksMinocycline:
1. Is neuroprotective.
2. Reduces brain inflammation
3. Reduces the number of glutamate receptors.
4. Demonstrates antidepressant properties in mouse models of depression.
5. Is reported to act synergistically with noradrenergic antidepressants to treat depression - desipramine (but not fluoxetine).
6. Is reported to act synergistically with NMDA antagonists.
7. Reduces glutamate excitotoxicity by reducing the formation of quinolic acid, a NMDA agonist.
8. Reduces mitochondrial release of cytochrome C.
9. Modulates several signaling pathways.
10. Reduces microglial activation.
11. Has been reported anecdotally to successively treat depression.
12. Reduces the expression of lipopolysaccharide-induced pro-inflammation cytokines, an effect that acts as an antidepressant in animal models.
13. Increases neurite growth in response to nerve growth factor (NGF).
14. Inhibits high levels of PKC and GSK-3 alpha;
15. Decreases nitric oxide synthetase, thereby reducing free radicals which damage neurons and glia.
16. Reduces glutamate release.It has been suggested that minocycline might act synergistically with Lamictal to reduce glutamate activity and improve depression.
The following article contains a review of the rationale for using minocycline to treat mood disorders:
http://bmjopen.bmj.com/content/2/1/e000643.full
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1036590
URL: http://www.dr-bob.org/babble/20130124/msgs/1036955.html