Posted by SLS on January 2, 2013, at 0:12:35
In reply to Re: Med decisions to make. Input welcomed. » jono_in_adelaide, posted by Phil on January 1, 2013, at 22:38:46
Phil, your manic reaction to abruptly discontinuing amitriptyline is not without precedent, and probably indicates bipolarity. Even if depression is your only problem now, its biological underpinnings might be closer to being bipolar than unipolar.
> I guess. I went to the ultimate authority, Crazy Meds(love that guy), and read up a bit on Geoden. We'll see.
Geodon and Latuda are chemical cousins, and are both less likely to produce weight gain than the other APs. Geodon can produce an antidepressant effect, perhaps by acting as a mild SNRI along with its AP effects. However, some people become activated or agitated on it. In fact, according to Stephen Stahl, a low dosage of 20 mg/day is more likely to do this than higher dosages. Anxiety and insomnia can occur at any dosage. Latuda is less apt to produce these side effects, perhaps because it has no SNRI properties. Both drugs also blocks serotonin 5-HT7 receptors. This receptor is increasingly being seen as important in the pathogenesis of depression. Risperdal is another drug that does this.
I would probably try Geodon first. If anxiety and insomnia become problems, you can cross over to Latuda. If that drug proves unsuitable, then I would try Saphris (asenapine) before circling back to Seroquel. I have seen this drug act to energize a friend of mine, while reducing delusions and ruminations. She sleeps very well. It hits a bunch of receptors.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1034355
URL: http://www.dr-bob.org/babble/20121231/msgs/1034405.html