Posted by SLS on December 29, 2012, at 13:54:26
In reply to Re: TRD MAOI heads. Tranylcip + Nortrip + Stimulants?, posted by metamorphosis on December 29, 2012, at 9:14:04
> Also, are there major benefits of using nortriptyline over amitriptyline?
Only if you do not tolerate the side effects of amitriptyline. Otherwise, you probably have a greater chance of responding to amitryptyline than to nortriptyline. Antichoinergic and sedative side effects are much reduced with nortriptyline. However, the amitriptyline might help you sleep. In order to receive the full benefit from either of these drugs when combined with an MAOI, one must usually take a dosage that would otherwise be effective if the drug were used alone. That would require a dosage of 150 mg/day of amitriptyline or 75 mg/day of nortripytyline. However, you would still want to titrate each drug gradually. My only concern with taking amitriptyline in combination with a MAOI would be the development of serotonin syndrome. Amitriptyline would be less apt to do this than imipramine or clomipramine, but it is still theoretically possible. I would not let that be the deciding factor in choosing amitryptyline, though. You would probably want to take your entire daily dose of amitriptyline at night.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1033062
URL: http://www.dr-bob.org/babble/20121217/msgs/1034137.html