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question for SLS » SLS

Posted by g_g_g_unit on December 29, 2012, at 1:41:32

In reply to Re: feel finished - GGG » g_g_g_unit, posted by SLS on December 28, 2012, at 7:11:39

Hey SLS, I'm not sure whether you'll be able to answer this or not, but I'm not currently on any meds -- and my psychiatrist only returns from vacation in three weeks -- so I kind of have some room to experiment.

Anyway, I have a bunch of Memantine lying around. I tried it in doses varying from 2.5 - 15mg, but found that it increased my anxiety/OCD and caused agitation.

I read a post from phiddipus stating that 5-HT3 affinity increases at 20mg, and thus it enhances GABA activity and becomes more anxiolytic. I can't find anything that confirms that and haven't read of anyone noticing a subjective difference in effect with different doses -- in fact, my adverse reaction seems to be quite out of the ordinary. Overall, from studies etc., it seems to be a really well-tolerated drug, which is why my response confused me.

That said, do you think it would be worth experimenting with taking 20mg a day for a little while and seeing how I respond? Do you know of many people who have experience with the drug and possibly responded better at a higher doses? Is it possible to speculate whether the increased NMDA antagonism etc. could possibly be more beneficial?

It's hard to know whether attempting to self-medicate when feeling so out-of-control etc. might be worse for me -- and whether it might be better to just secede control over to the hospital -- but I also thought I might get lucky (for once) and didn't have anything to lose, other than some transient discomfort.

 

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poster:g_g_g_unit thread:1033817
URL: http://www.dr-bob.org/babble/20121217/msgs/1034117.html