Posted by Beeb on December 22, 2012, at 17:08:42
In reply to Re: clonazepam/Klonopin and HPA axis issues, posted by SLS on December 22, 2012, at 13:57:13
> > Ive also read that klonopin increases/decreases or just affects serotonin in some way.
>
> Yup. Confusing, isn't it? I have seen the older studies, and they do report contradictory results.
>
> When I discontinued chronic Klonopin (clonazepam) and went through withdrawal, I experienced severe "brain-zaps" that I don't recall experiencing with Ativan (lorazepam) discontinuation. It was reminiscent of SSRI / SNRI withdrawals. I wonder if this is an artifact of changes in 5-HT function produced by clonazepam. One would think that the brain-zaps would be consistent with a sudden decrease in 5-HT activity. Does this mean that clonazepam somehow enhances 5-HT neurotransmission?
>
> This study is old, but looks pretty good:
>
> http://www.ncbi.nlm.nih.gov/pubmed/520416
>
>
> - ScottThere is so much 'out there'. It seems that the anti absence and myoclonic actions of clonazepam (its specialty) are mediated through GABAB/serotonin (connection). There are many articles about the relationship between serotonin and GABAB.
The 'thalamic nucleus reticularis' may be the key.
See also thalamus.
A few links, some very technical stuff:http://link.springer.com/article/10.1007%2FBF02740750?LI=true
http://www.ncbi.nlm.nih.gov/pubmed/7931539
http://www.sciencedirect.com/science/article/pii/S0387760497001071
If you like: edoc.unibas.ch/212/1/DissB_7136.pdf
poster:Beeb
thread:1033537
URL: http://www.dr-bob.org/babble/20121217/msgs/1033562.html