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Medical Food Aids in the Treatment of Major Depres

Posted by firemonkey on December 11, 2012, at 3:36:22

Medscape Medical News > Psychiatry
Medical Food Aids in the Treatment of Major Depression

Adjunctive L-methylfolate is safe, effective, and "relatively well tolerated" for patients with major depressive disorder (MDD) who are resistant to selective serotonin reuptake inhibitors (SSRIs) alone, new research suggests.

A randomized controlled trial (RCT) of 75 adults with MDD showed that the participants who received 15 mg/day of L-methylfolate in addition to continued SSRI treatment showed significantly higher response rates and depression symptom score changes than those who received placebo plus continued SSRI therapy.
Dr. George Papakostas. Source: Massachusetts General Hospital

In this trial, "15 mg/day of adjunctive L-methylfolate appeared to result in a treatment outcome (efficacy) superior to continued SSRI therapy plus placebo in both primary outcome measures," George Papakostas, MD, from the Center for Treatment-Resistant Depression at Massachusetts General Hospital in Boston and from Harvard Medical School, told Medscape Medical News.

The researchers note that this is the first randomized, double-blind, placebo-controlled trial to examine these outcomes in this particular patient population. Although the results were positive, replication is needed, they add.

Initially presented at the European Congress of Psychiatry in 2011 and reported by Medscape Medical News at that time, the study is published in the December issue of the American Journal of Psychiatry.


http://www.medscape.com/viewarticle/775953


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poster:firemonkey thread:1032812
URL: http://www.dr-bob.org/babble/20121130/msgs/1032812.html