Posted by ed_uk2010 on December 4, 2012, at 8:44:30
In reply to Re: P-glycoprotein and psychiatry, posted by rjlockhart37 on December 3, 2012, at 21:26:53
>I drink red bulls and coffee....nothing...i mean ALOT of coffee, ... nothing but acid in the stomach...there's something blocking this from doing it.
That's not unusual, not everyone gets much effect from caffeine. It doesn't mean you're not absorbing it, it just means that what caffeine does in the brain doesn't create a stimulant effect for you.
With respect to meds which used to have a stronger effect than they do now, this is not unusual either. Tolerance can occur to a variety of psych meds due to adaptations in the brain which oppose their effects. The drug still gets into the brain, but it's not able to exert such a potent effect when it gets there. Tolerance is especially common with stimulants and benzodiazepines. Also, drugs which exert a sedative effect which is partly due to antihistamine activity (eg. some antipsychotics) tend to get less sedative over time.
poster:ed_uk2010
thread:1032198
URL: http://www.dr-bob.org/babble/20121130/msgs/1032444.html