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Re: Doc wants to try high lyrica dose for Anxiety/SF » Tepi

Posted by phidippus on October 14, 2012, at 18:54:07

In reply to Re: Doc wants to try high lyrica dose for Anxiety/SF » gilmourr, posted by Tepi on October 14, 2012, at 14:35:24

>it just increases GABA

Lyrica does no such thing. It has no affinity for GABA. Lyrica binds to the α2δ (alpha2delta) subunit of the voltage-dependent calcium channel in the central nervous system. Lyrica also decreases the release of neurotransmitters including glutamate, noradrenaline, substance P and calcitonin gene-related peptide.

Eric

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