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Re: Nardil Anxiety/Hyperrflexia..SLS? » gilmourr

Posted by ChicagoKat on October 5, 2012, at 11:57:58

In reply to Re: Nardil Anxiety/Hyperrflexia, posted by gilmourr on October 5, 2012, at 11:38:00

> I'm not giving up because I've been on 45 mg of Nardil twice now.
>
> Both times 70% of my depression and anxiety go away.
>
> This time though I've gone to 45 mg from 60 mg instead of starting Nardil from scratch. For some reason because of that, my anxiety isn't being helped to the same degree. It might still be that I need to wait longer, I'm now on day 27.
>
> Last time it took 30 days for the anxiety to reach 70% remission.
>
> I've tried Parnate and it's a side effect nightmare.
>
> If Nardil doesn't work at 45 mg after 8 weeks or so after coming
> down from 60 mg, then I'll go off it for 2 weeks and start from 0 again. It will 100% work that way.
>
> But I still strongly believe it has to work coming down from 60 mg. I don't see why it wouldn't.
>
> ** And I don't think a reversible MAO inhibitor would cut it. Maybe selegiline might, but Nardil works, it's just being weird this time.

Nardil is a truly wonderful drug, but it certainly can behave strangely. Probably due to the way it inhibits those enzymes, then takes it's own sweet time disinhibiting them. Not to mention that it self-metabolizes. I have to say, almost the minute I start Nardil my anxiety disappears, and it stays that way all the while I'm on it. It's wonderful. But, on my first try with it I developed ataxia (incoordination) from it and suffered falls when I was at 60mg/day. We stopped it and tried absolutely everything else we could think of including stimulants, but nothing worked or I developed bad side effects, eg, severe anxiety from Ritalin, which had helped for several months. Who knows why drugs turn on us? Maybe Scott has some input. And I do know he said something (I think it was him) that Nardil is the only MAOI that has anti-anxiety properties, something to do with how it interacts with GABA, plus another mechanism. I can't remember now. But maybe your problem has something to do with these mechanisms being saturated or something, I do not know, but it must have something to do with these mechanisms. Maybe Scott will chime in; that would help..he really know his stuff. Hope things work out for you.
Kat


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poster:ChicagoKat thread:1027396
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