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Re: Jono, sorry to bother you, but need rpt info » ChicagoKat

Posted by SLS on October 2, 2012, at 13:25:54

In reply to Re: Jono, sorry to bother you, but need rpt info » SLS, posted by ChicagoKat on October 2, 2012, at 9:02:33

> But I've been meaning to ask you, to ask you all, actually...do you know of any interactions between smoking and Nardil or Nortryp? I mean like kinetic and metabolic interactions that could lower blood concentrations, that sort of things. I've checked my references and they've mentioned nothing, but I thought I'd pass it by you too.

There should be no pharmacokinetic interaction between Nardil and nortriptyline.

I reviewed the metabolism of Nardil recently, and I could find no data indicating that cytochrome enzymes are involved. Nor does it seem that Nardil inhibits any. Tricyclics are metabolized by cytochrome enzymes. The main metabolic pathway for Nardil metabolism is actually oxidation via MAO. Nardil inhibits its own metabolism. Nardil is also metabolized via acetylation, albeit to a lesser extent.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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