Posted by phidippus on September 22, 2012, at 1:39:22
In reply to Low dose Trazodone with Nortriptyline, posted by schleprock on September 19, 2012, at 11:31:38
Trazodone acts predominantly as a 5-HT2A receptor antagonist to mediate its therapeutic benefits against anxiety and depression. Its inhibitory effects on serotonin reuptake and 5-HT2C receptors are relatively weak (~15-fold lower than for 5-HT2A) and contribute only lightly to its overall effects. Hence, trazodone does not have similar properties to selective serotonin reuptake inhibitors (SSRIs).
>so as to make more serotonin available than >nortriptyline alone?
At 50 mg, Trazadone's effects will be negligible. A dose of 200-400 mg might be more useful.
>Has it ever been done? Is it safe?
I'm sure it's been done before. I looked into drug reactions and couldn't find any between Trazadone and Nortryptaline.
>What about side effects?
Headache or heaviness in head
Nausea, vomiting, or bad taste in mouth
Dry mouth
Stomach pain
Diarrhea
Constipation
Changes in appetite or weight
Weakness or tiredness
Nervousness
Decreased ability to concentrate or remember things
Confusion
Brain fog or "zombie-like" sensations
Nightmares
Muscle pain
Sweating
Blurred vision
Tired, red, or itchy eyes
Ringing in earsChest pain
Fast, pounding, or irregular heartbeat
Shortness of breath
Fever, sore throat, chills, or other signs of infection
Hives
Skin rash
Itching
Difficulty breathing or swallowing
Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
Hoarseness
Decreased coordination
Uncontrollable shaking of a part of the body
Numbness, burning, or tingling in the arms, legs, hands, or feet
Dizziness or lightheadedness
Fainting
Painful erection that lasts longer than normal-That's Trazadone's side effect profile from Wikipedia
>How would this choice compare with other commonly used meds in this class (SARI)?
There are other drugs in this class, but they are not available in the US.
Eric
poster:phidippus
thread:1026110
URL: http://www.dr-bob.org/babble/20120912/msgs/1026340.html