Posted by phidippus on September 20, 2012, at 9:19:13
In reply to Re: i never tried any TYPICAL ANTI PSYCHOTIC!!! » phidippus, posted by SLS on September 18, 2012, at 23:49:25
Firstly, Haloperidol's neglible affinity for histamine H1 receptors and muscarinic M1 acetylcholine receptors yeilds an antipsychotic with a lower incidence of sedation, weight gain and orthostatic hypotension
Its a 5HT1A Agonist (Ki 1927nM), a 5HT7 antagonist (Ki 377.2nM)and Dopamine D3 inverse agonist (0.74nM). All of which should help with both negative and positive symptoms of schizophrenia.
It also seems to have a wide variety of applications and seems more flexible than a lot of other antipsychotics.
Haloperidol is also considered indispensable for treating psychiatric emergency situations-it seems offered in every ER.
Drawbacks include Depression, severe enough to result in suicide, is quite often seen during long-term treatment. Also the incidence of extra pyramidal symptoms is on the high side