Posted by ChicagoKat on September 19, 2012, at 19:20:18
In reply to Re: Need out of the box suggestions » ChicagoKat, posted by SLS on September 19, 2012, at 18:57:57
> > Too bad there aren't any MAO-A reversible inhibitors in the US, as there are in Europe.
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> Just a quick FYI:
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> The RIMAs don't seem to work nearly as well as the irreversibles. They tend to poop-out quickly. Moclobemide underwent clinical trials in the US for social anxiety 20 years ago, but was abandoned for lack of efficacy. Having a few irreversible inhibitors of MAO-A would be nice. Clorgyline worked very well, but was not developed because the patent had expired. Perhaps a new indication would bring it back. It seems to be therapeutically active in fungal infections and heart failure.
>
> Brofaromine was available for a short period of time in a few countries in Europe. It probably worked better than moclobemide, but perhaps not good enough. Maybe there was a safety issue. Maybe a business decision. I don't know. If I remember correctly, brofaromine was a serotonin reuptake inhibitor in addition to being a RIMA. This is not a good combination.
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> - ScottThanks for the info Scott!
poster:ChicagoKat
thread:1025287
URL: http://www.dr-bob.org/babble/20120912/msgs/1026154.html