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Re: (maybe) working for me too rovers95

Posted by SLS on September 18, 2012, at 18:30:51

In reply to Re: (maybe) working for me too SLS, posted by rovers95 on September 18, 2012, at 15:57:32

> > Minocycline is still working...
> >
> > ...better and better.

> Okay, whilst it is difficult for me to discern what represents a response from what is a 'high' from eating a few carbs, I seem to be doing a lot better. I am now at 100mg and whilst I was quite flat friday to sunday, in the last few couple of days I have good spells that suggest considerable improvement.

That mirrors my experience with minocycline. I felt flat for the first few days, but felt better going into day 5. Your mood might be somewhat variable throughout the day at first. Mine was. It is less so now.

> Obviously, I have issues in other areas (binge eating, diet)that need addressing. I was considering suggesting an SSRI (zoloft) or using 5htp to see if this would help this side of my treatment.

Have you tried Prozac? What about desipramine or other TCAs? One study of rats showed that minocyclne helped desipramine work better. The same was also true of Prozac, but in a different manner. The other SRIs might work just as well, but they weren't tested.

> Scott, would be interesting to know what made you try minocycline...

It was a suggestion coming from the psychiatry department at Massachussets General Hospital.

> Is your pdoc using with others?

I'm his first.

Fortunately, my doctor has an open mind. I didn't have to work too hard to convince him to allow me to try minocycline. He's big on some of the newer ideas regarding brain inflammation. Although I am convinced that there is an association between inflammation and depressive illness, I tend to believe that the anti-glutamatergic properties of minocycline are most responsible for its more immediate antidepressant effect. I could be very wrong, of course.

> do you know of anyone who has been on this long term?

Not yet.

What other drugs are you taking?


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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