Posted by schleprock on August 19, 2012, at 18:08:15
In reply to Re: Nortriptyline + Effexor: A good combo? » schleprock, posted by phidippus on August 19, 2012, at 17:34:21
> Why would raising the Nortryptaline be unsafe?
>
> It would be nice to add an antidepressant with a complimentary mode of action.
>
> Eric150 mgs is Nortriptylines is conventional maximum dosage, I don't think my pdoc would raise it, and my plasma levels are already slightly above the reference range.
I've heard that clomipramine is perhaps the best AD for depression, but I don't know enough about pharmaceuticals to determine whether adding another tricyclic would increase nortriptyline toxicity.
Effexor seems like it might be the best augment going beyond the tricyclic class, but I'm just thinking it's easier to deal with augments from a class I'm already familiar with. Is there a more logical tricyclic than clomipramine that would compliment the regular action of Nortriptyline.
I'm not sure how relevent it is, but there was a study that determend Nort. + Clomi. was more effective for OCD than one of them alone (too bad I don't have OCD). Presumably that would indicate at least that they're safe to take together.
poster:schleprock
thread:1023542
URL: http://www.dr-bob.org/babble/20120818/msgs/1023686.html