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Re: Nardil and falls

Posted by SLS on August 5, 2012, at 2:06:49

In reply to Re: Nardil and falls » chicagokat, posted by viper1431 on August 4, 2012, at 19:32:40

> Yeah 3 weeks sounds about the same for me.
> It's always gone away. I actually use the drunk stumbling as a sign that it's starting to work properly and that's when i lower the dose for a few days (or even stop for a few days) otherwise i do get to the point where if i don't sit down right away i know i will just collapse. When it has stopped i then up the dose again and it usually doesn't happen anymore.
>
> I just have to watch out for the ortho hypotension after that.
>
>
>
> > > How long had you been on the Nardil? After i've been on it for a short while i go through a period where i'll be walking around (always seems to happen when i'm at the shopping centre just to make it more intresting) where i'll be walking like i'm a little drunk, so far it hasn't gone beyond stumbling though thankfully.
> > >
> > > > Hello,
> > > >
> > > > Has anyone else ever been on Nardil and experienced the side effect of ataxia (incoordination) that led to falls? I had 4 falls while on Nardil-it was like one minute i was up and the next, boom, I was down.
> > > >
> > > > If you have ever experienced this, what did you and your doc do about it? In my case my doc took me off the Nardil, which was a crying shame b/c it was working so well
> > > > Thanks,
> > > > Kat
> > >
> > >
> >
> > I had been on Nardil about 3 weeks when the symptoms started...and it was just like you: walking like I was drunk at first, then I guess it started getting more severe cos I'd be walking (stumbling) along and one second I'd be up and the next I was flat on my face. You're lucky you never got to the point where you had falls....tell me, did the stumbling eventually go away? If it did, maybe I could tell my pdoc and tell him I'll use a walker and wear a helmet (ha ha) until the ataxia wore off. That would be better than feeling as awful as I do now b/c the Nardil REALLY made me feel better.
> > Thanks,


Interestingly, when Nardil makes me feel weird, foggy, and otherwise "drunk", it means that the drug is going to work. These side effects occur once I reach a dosage of 60 mg/day. They always go away. Unfortunately, with me, the more robust antidepressant response is transient, although I can remain partially improved for an extended period of time.

The walking up a flight of stairs thing is probably transient low blood pressure. As one climbs the stairs, the large muscles of the legs contracting rhythmically act as secondary pumps to move blood around, and the heart is "told" by the CNS via baroreceptors that it can beat less forcefully. Once the secondary pumping action stops abruptly at the top of the stairs, there is a lag time before the heart is told to resume its normal forcible contractions. Actually, much of these changes in blood pressure are determined by changes in blood vessel dilation and constriction. As a side effect, these transient dizzy spells might not disappear entirely, but they can mitigate to some degree over time.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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