Posted by johnb123 on May 10, 2012, at 7:18:09
Hi.
I want to share a theory with you so I can get some good input.
Since about since i was 15 (24 now) I have been having trouble with concentration and often "zoning out". However when there is a subject i really like then my concentration is "superior" however I get like into some bubble and can only think about this subject.
About a year ago I did a DNA-test with 23andMe and it turns out I have "http://www.snpedia.com/index.php/Rs1800497" , "This allele (rs1800497(T)) is associated with a reduced number of dopamine binding sites in the brain". And this acutally makes alot of sense.
Before the test I was very depressed and I unfortunetaly tried amphetamine which, at the time, felt like the best thing ever.
However after that , even if it was just one time, i have an even harder time to concentrate , have fatigue, and think that things i thought was funny before ain't funny anymore.
Downregulation?
I also now get angry and anxious easier with minimal stress.
After that I tried Lexapro which helped abit in the beginning but after about a month I was fatigued etc again but the anxiousness had gone away.
The theory I came up with (without any real knowledge about this, please tell me if this can be correct) is that because I have a low D2 receptor count then, of course, my brain is taking up less of the dopamine i have, AND (my theory) more dopamine is converted to norepinehrine and thus contributing to the anger and anxiety.
Does it work like this? ;) Is this related to ADHD/ADD?
Maybe the reason the SSRI worked good in the beginning was because it hijacked (i read that somewhere) the dopamine signaling.
If so,
1. What would be the best way to upregulate the D2 receptors
2. Is there any medication (preferebly non narcotic in single dose) that can confirm my theory? Should it be something that blocks DAT?
Thank you :)
poster:johnb123
thread:1017618
URL: http://www.dr-bob.org/babble/20120508/msgs/1017618.html