Posted by SLS on April 10, 2012, at 8:29:15
In reply to Re: Abilify + TCA? » SLS, posted by tensor on April 10, 2012, at 7:46:14
> > > It made me a little tired and some headache. I talked to a person who did not respond to 200mg but had a good response at 300mg.
> >
> > It happens. If you don't experience significant cognitive impairments at higher dosages, it might be worth pursuing.
> >
> > > Maybe all I needed was higher dose? Only one way to find out, I guess.
> >
> > Things happen between Lamictal and Abilify that are synergistic and may involve the potentiation of dopamine activity. My doctor has had success combining Lamictal with Wellbutrin. It sounds as if you have not exhausted your options. This is a good thing.
>
> What is the mechanism behind that, do you know?
Lamictal: My guess after researching the matter is that Lamictal increases DA in the nucleus accumbens via disinhibition as glutamate release is inhibited in the thalamus.Abilify: Limbic DA activation via D2/D3 receptor partial agonism and 5-HT1a receptor partial agonism.
> I'm taking 45mg of Remeron and 150mg of nortrip now. I was thinking that replacing Remeron with Lamictal would be a good move. Then I can give nortrip a little more time to prove itself since the slow titration of Lamictal.That's a great move in my opinion.
> I'm not sure when or how to introduce Abilify to my regime, I know my pdoc is not keen on starting two meds at the same time. I will see him in two days.
If you are unipolar, starting Abilify at a very low dosage probably makes the most sense. You can start at 1.25 - 2.5 mg and work up to 5 mg if needed. If you are bipolar, you might need to go up to 10 mg.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1013816
URL: http://www.dr-bob.org/babble/20120328/msgs/1015317.html