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Re: Adding Parnate and prazosin. SLS

Posted by ed_uk2010 on March 17, 2012, at 13:59:08

In reply to Re: Adding Parnate and prazosin. ed_uk2010, posted by SLS on March 16, 2012, at 13:19:26

>Does doxazosin cross the BBB as readily as prazosin?

I did find a bit of information. It said that doxazosin is less lipid-soluble than prazosin and may not cross the BBB very well. So, I guess doxazosin might not be as effective.

One thing about prazosin is the short half-life, apparently only 2-3 hours. What do you think of the idea of taking smaller doses more frequently?

> I couldn't find an answer to this question. Maybe you will have better luck.
> I found a few studies that reported doxazosin as being effective in treating PTSD. It would certainly be an attractive alternative to prazosin if this were true.
> - Scott




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