Posted by g_g_g_unit on March 15, 2012, at 7:04:58
In reply to Re: Prescribed Clonidine for Parnate insomnia » g_g_g_unit, posted by SLS on March 15, 2012, at 6:35:17
Thanks Scott. I realize it's mostly the stimulant effect at play, but I've noticed some interesting improvements in cognition and ADD symptoms (more so than any other AD), so I'd like to find a way to continue with the Parnate. I understand, though, that tolerance will (?) develop to those effects.
Anyway, I'm hopeful about clonidine. My psych thinks it might even act synergistically with the Parnate to improve ADD. I just hope I don't experience an increase in depression on it.
> I should think that clonidine is better for insomnia than prazosin. Clonidine is a more potent sympatholytic (anti-flight-or-flight) than prazosin. They work on different parts of the nervous system.
>
> clonidine = NE alpha-2 agonist
> prazosin = NE alpha-1 antagonist
>
> Although I am not the drug's biggest fan, Gabitril (tiagabine) is sometimes used to treat insomnia. It enhances slow wave sleep and sleep maintenance. Gabitril is unique as a reuptake inhibitor of GABA. Personally, I think the drug is unpredictable interindividually. It can be agitating for some people. However, if it works well for a given individual, it should keep working well.
>
> Please keep us updated. I am very interested to see how clonidine affects you.
>
> Good luck.
>
>
> - Scott
>
poster:g_g_g_unit
thread:1013094
URL: http://www.dr-bob.org/babble/20120302/msgs/1013114.html