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Re: Adding Parnate and prazosin. » sigismund

Posted by SLS on March 4, 2012, at 7:24:29

In reply to Re: Adding Parnate and prazosin., posted by sigismund on March 3, 2012, at 23:44:12

> My sleep is significantly smoother for having added prazosin. I experience fewer awakenings. Experiments have shown that prazosin and clonidine each increase the spectral power of delta-wave (slow-wave) sleep as seen on an EEG. This should produce a greater period of time spent in deep sleep. I hope prazosin helps you.

Speaking of polypharmacy, if prazosin helps, but is not wholly adequate, you can add clonidine to augment the prazosin. I don't know if anyone has tried this for PTSD, but it makes sense to me. If taken at night along with prazosin, any tendency towards dizziness might dissipate by morning. I'm not sure. Both clonidine and prazosin are used to treat hypertension. I don't know if the two drugs are synergistic with respect to lowering blood pressure. By the way, at 6 mg/day of prazosin, my blood pressure while seated is normal (120/76). I experience some mild to moderate orthostatic hypotension. Note that I am taking Parnate at the same time, which, itself, causes dizziness.

Topamax is also good for treating PTSD, just in case you are thinking along those lines. I don't know if it affects sleep architecture at all.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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