Posted by linkadge on February 20, 2012, at 19:17:35
In reply to Linkadge, I could use your help., posted by SLS on February 20, 2012, at 17:46:23
Hmm. Some of the things that come to mind are:
Over-activation in parietal / occipital regions (a trait marker in familial depression)? Glutmate levels appear to be elevated even in non-depressed offspring.
http://users.ox.ac.uk/~psyc0288/ray_page/int_j_neuropharm.pdf
Low gaba (and hence elevated glutamate?) in the occipital lobes has also been found in other studies of depression. Gaba levels are elevated by successful SSRI treatment.
http://ajp.psychiatryonline.org/article.aspx?Volume=161&page=368&journalID=13
Glutamate has been shown to be elevated in the prefrontal cortex of depression and bipolar disorder. In stress induced models of depression, the prefrontal cortex appears particularly sensitive.
http://www.medwire-news.md/56/71246/Depression/Glutamate_elevated_in_brains_of_mood_disorder_patients.htmlThe only other regions that come to mind are limbic regions and as you mention Broadmann's area 25. The area 25 serves as kind of a gateway of the feedback loop between the prefrontal regions and limbic regions. I think some studies have linked depression to reduced volume in the cingulate area. The reduced volume might cause inefficient filtering of incoming stimuli and hence over activation of both regions.
Linkadge
poster:linkadge
thread:1011014
URL: http://www.dr-bob.org/babble/20120212/msgs/1011032.html