Posted by g_g_g_unit on February 16, 2012, at 5:34:27
In reply to Re: parnate agitation » g_g_g_unit, posted by SLS on February 16, 2012, at 3:11:25
> > Just an update: I saw my psychiatrist today. He believes irritability is a potential side-effect of increased adrenergic activity and doesn't necessarily point to Bipolar.
> >
> > Regardless, he's prescribed Depakote (250-500mg) to take in the meantime in the hope that it might curb side-effects and allow me to reach a higher dose of Parnate.
> >
> > I asked about clonidine for sleep. He's going to look into its safety and also thinks it might be a useful option to control overstimulation.
>
>
> I like what your doctor had to say.
>Yeah, he's a smart guy. I kind of wish he'd opted for something like klonopin - I thought it might be easier to reap an instant effect, and that it would also help insomnia. But he isn't a big fan, alas.
> If you do opt for clonidine, be aware that a rather sizable percentage of people experience depression as a side effect. However, it might be exactly what you need as a sympatholytic. Prazosin, another sympatholytic drug, is sometimes used in PTSD to reduce anxiety and improve sleep. Of course, there is propranalol.
>
> http://www.consumerreports.org/health/best-buy-drugs/prazosin-for-ptsd/overview/index.htm
>
> "Prazosin is the most thoroughly studied drug in regard to PTSD and sleep among the class of medications known as alpha-1 blockers. In addition to preventing nightmares and insomnia, it can help improve overall symptoms, such as flashbacks, startle response, and irritability or anger, and it can be taken with an antidepressant."
>
> Good luck.
>
>
> - Scott
Thanks for the tip, Scott. It seems Prasozin is available here. However, didn't you say it decreases DA in the nucleus accumbens? Wouldn't that exacerbate anhedonia?
poster:g_g_g_unit
thread:1009862
URL: http://www.dr-bob.org/babble/20120212/msgs/1010425.html