Posted by Hugh on February 7, 2012, at 16:43:09
In reply to Re: Ketamine: Replication of previous studies., posted by jono_in_adelaide on February 6, 2012, at 16:22:17
> I'd consider it if nothing else had helped, I'd rather try ketamine than submit to ECT for example.
>
> I know that when used as an anaesthetic it produced side effects (bad dreams, halucinations) but the dose in depression would be way lower, and I beleive that benzodiazepines greatly reduced the side effects.
>
> All we need now is a drug company to have the balls to get it to market in pill form.There are at least two ketamine-like antidepressants without ketamine-like side effects that are currently being tested. AstraZeneca is working on an NMDA antagonist called AZD6765. It's in phase II trials. Naurex is conducing a phase II trial of GLYX-13, a glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor (NMDAR). Magnesium is an NMDA antagonist, but it has a hard time crossing the blood-brain barrier. MIT recently developed a new form of magnesium called magnesium l-threonate that's much better at crossing the blood-brain barrier. It only became available last year. I haven't tried it yet, but I will soon.
poster:Hugh
thread:1009454
URL: http://www.dr-bob.org/babble/20120202/msgs/1009589.html