Posted by SLS on January 18, 2012, at 8:18:38
In reply to can i give up now?, posted by Elanor Roosevelt on January 18, 2012, at 3:47:47
> Are there places where you can get opiates prescribed for depression?
Supposedly, but I don't know where they are. Some doctors are willing to try buprenorphine, which is an opioid that has few studies supporting its use in depression.
Everyone always cites the same one study found below. My doctor is not at all persuaded by it.
Give up?
No one can know your history of pain and your tireless efforts to relieve it. Often, crisis feelings of wanting to give up recede with the passage of time. It could be a matter of days or weeks. I hope it passes quickly for you. Your outlook is probably overwhelmingly stricken with feelings of hopeless and helplessness. How could it not be?
Please take life one moment at a time during this bad period. You know your options. Try not to act on them, as it is probably premature to do so. The bad time is likely to pass, even if you don't see how it possibly could. It will.
Do the best you can. Things should get easier soon. Your situation won't necessarily change, but your outlook will. You will become once again positive and constructive in attending to your challenges.
I talk too much. Sorry.
- Scott
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http://www.ncbi.nlm.nih.gov/pubmed/7714228
J Clin Psychopharmacol. 1995 Feb;15(1):49-57.
Buprenorphine treatment of refractory depression.
Bodkin JA, Zornberg GL, Lukas SE, Cole JO.
SourceMcLean Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Belmont, MA 02178, USA.
AbstractOpiates were used to treat major depression until the mid-1950s. The advent of opioids with mixed agonist-antagonist or partial agonist activity, with reduced dependence and abuse liabilities, has made possible the reevaluation of opioids for this indication. This is of potential importance for the population of depressed patients who are unresponsive to or intolerant of conventional antidepressant agents. Ten subjects with treatment-refractory, unipolar, nonpsychotic, major depression were treated with the opioid partial agonist buprenorphine in an open-label study. Three subjects were unable to tolerate more than two doses because of side effects including malaise, nausea, and dysphoria. The remaining seven completed 4 to 6 weeks of treatment and as a group showed clinically striking improvement in both subjective and objective measures of depression. Much of this improvement was observed by the end of 1 week of treatment and persisted throughout the trial. Four subjects achieved complete remission of symptoms by the end of the trial (Hamilton Rating Scale for Depression scores < or = 6), two were moderately improved, and one deteriorated. These findings suggest a possible role for buprenorphine in treating refractory depression.
PMID:
7714228
[PubMed - indexed for MEDLINE]Publication Types, MeSH Terms, Substances, Grant Support
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