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Re: Mirtazapine + Viibryd » williamockham

Posted by Phidippus on December 13, 2011, at 17:57:28

In reply to Re: Mirtazapine + Viibryd, posted by williamockham on December 12, 2011, at 8:19:46

>theoretically would increase serotinergic >transmission via alpha-2 antagonism.

I take another medication which has been extremely helpful for my OCD, Prazosin. Prazosin is an alpha-adrenergic blocker, type 1. It is hypothesised that prazosin in combination with a Serotonin Reuptake Inhibitor (SRI) might possess an anti-obsessive compulsive disorder (OCD) modulating effect by raising dopamine (DA) levels in the synaptic cleft in the prefrontal cortex and inhibiting extracellular DA concentrations in the nucleus accumbens. I wonder if Mirtazapine does much the same thing.

>the jury is still out on whether 5HT2 >antagonists help with OCD.

Antagonism of 5-HT2C receptors results in an increase of dopamine and norepinephrine activity in the frontal cortex. 5-HT2C receptors significantly regulate mood, anxiety, feeding, and reproductive behavior.

Seems reward pathways benfit from 5ht2 antagonism.

Eric


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