Posted by Phidippus on December 13, 2011, at 17:57:28
In reply to Re: Mirtazapine + Viibryd, posted by williamockham on December 12, 2011, at 8:19:46
>theoretically would increase serotinergic >transmission via alpha-2 antagonism.
I take another medication which has been extremely helpful for my OCD, Prazosin. Prazosin is an alpha-adrenergic blocker, type 1. It is hypothesised that prazosin in combination with a Serotonin Reuptake Inhibitor (SRI) might possess an anti-obsessive compulsive disorder (OCD) modulating effect by raising dopamine (DA) levels in the synaptic cleft in the prefrontal cortex and inhibiting extracellular DA concentrations in the nucleus accumbens. I wonder if Mirtazapine does much the same thing.
>the jury is still out on whether 5HT2 >antagonists help with OCD.
Antagonism of 5-HT2C receptors results in an increase of dopamine and norepinephrine activity in the frontal cortex. 5-HT2C receptors significantly regulate mood, anxiety, feeding, and reproductive behavior.
Seems reward pathways benfit from 5ht2 antagonism.
Eric
poster:Phidippus
thread:1004746
URL: http://www.dr-bob.org/babble/20111208/msgs/1004914.html