Re: what other than zyprexa? » B2chica

Posted by Phidippus on November 22, 2011, at 18:41:53

In reply to what other than zyprexa?, posted by B2chica on November 21, 2011, at 15:38:59

Zyprexa does do its job well. Olanzapine has a higher affinity for 5-HT2 serotonin receptors than D2 dopamine receptors. Other affinities are (Ki, nM):
dopamine D1: 31
dopamine D2: 11
serotonin 5-HT2A: 4
serotonin 5-HT2C: 11
muscarinic M1: 79
adrenergic alpha1: 19
histamine H1: 7
SO, Zyprexa likes to block seratonin receptors, but still hits dopamine receptors as well.
I have been on most or all of the AAPs and my recommendation would be Invega. Of all the AAPs, Invega feels closest to Zyprexa.
Eric

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what other than zyprexa? B2chica 11/21/11
Re: what other than zyprexa? jono_in_adelaide 11/21/11
Re: what other than zyprexa? creepy 11/21/11
Re: what other than zyprexa? Phillipa 11/21/11
Re: what other than zyprexa? Christ_empowered 11/21/11
Re: what other than zyprexa? » B2chica Zyprexa 11/22/11
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Re: what other than zyprexa? » B2chica Phidippus 11/22/11
Re: what other than zyprexa? bleauberry 11/23/11
Re: what other than zyprexa? SLS 11/23/11

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