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NE reduction?

Posted by Seige on November 17, 2011, at 3:16:06

Hi guys,

So I've figured out that the closest I get to feeling normal is when I'm withdrawing from medication that had an NE enhancing effect (buproprion, agomelatine, effexor, etc).

These meds all made me feel terrible in a specific way, a really heavy feeling, which I attribute to increased NE transmission. However a sudden stop, and I'll wake up the next day with this feeling I can only say is what being normal feels like. This will last for just under a week after any withdrawal.

I figure that during the period on the medication, the NE receptors have downregulated to compensate for the extra NE, and the sudden withdrawal leaves me with:

downregulated transmitters + no NE enhancing medication = overall reduced NE function

So that is what I am aiming for out of a medication. One strategy I have used in the past is to alternate 4 days on and off of buproprion, which affects me the strongest.

However, this isn't ideal and probably is frying my brain. I really think a medication which does something along the lines of only downregulating NE receptors would help. Do classes of medications exist which can replicate this effect? I'm guessing it would be something along the lines of norepinephrine reuptake enhancement, like tianeptine for NE.

Alpha antagonists might be one, though I'm not entirely sure. Have mentioned them to my psych, he was quite reluctant due to blood pressure issues.


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poster:Seige thread:1002855
URL: http://www.dr-bob.org/babble/20111110/msgs/1002855.html