Posted by pedr on October 7, 2011, at 8:25:37
In reply to Re: Nardil Maintenance Dose » pedr, posted by Chairman_MAO on October 7, 2011, at 7:08:32
Hi,
>
> http://archpsyc.ama-assn.org/cgi/content/abstract/35/5/629
>
> To sustain a robust response in the real world, ~1mg/kg is often needed.yes but this is just an abstract for a 6-week study, it doesn't mention maintenance dose at all.
> More to the point, I'd like to see some studies where they _did_ cut back to a maintenance dose, because I've only seen this in the monograph.
right. I've never seen such an article either during my wanderings through PubMed and so on. Some kind of data would be nice!
> Phenelzine also has an active metabolite that inhibits GABA-T. You will not get this in sufficient quantities to do anything on a "maintenance dose".
I'm unfamiliar with GABA-T but I figure that the logic you're referring to is something like :
a) GABA == anti-anxiety; relaxing agent [good]
b) GABA-T is GABA transaminase, an enzyme which catalyses GABA's breakdown [bad]
c) phenelzine is a GABA-transaminase inhibitor
d) transitioning to maintenance dose lowers Phenelzine's GABA-T inhibition
e) GABA-T subsequently increases and breaks down more GABA
f) less GABA == smaller calming effect == baddo you perchance have any good resources on this metabolite and its Pharmacokinetics etc. ?
Thanks,
PedrI love the smell of Nardil in the morning. The smell, you know that chemical smell. Smells like victory. Some day this war's gonna end...
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Atypical Depression, OCD, IBS-C, GERD since '96
poster:pedr
thread:998679
URL: http://www.dr-bob.org/babble/20111006/msgs/999008.html