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Re: 40% » SLS

Posted by uncouth on October 6, 2011, at 19:13:23

In reply to Re: 40%, posted by SLS on October 5, 2011, at 5:54:46

Scott, that is interesting what you mention about being on parnate and desipramine and being withdrawn, then having it NEVER work again. Were you on that MAOI for a long time?

Are you familiar with David Foster Wallace's story? He was on Nardil for something like 15 years, and he and his pdoc thought, hey my life is going well, i just got married, i'm settled, i'm dealing with my success pretty well these days, and i just had a bad med food reaction, maybe its time to try something else, because hey we've had a lot of advances in depression treatments since they started me on nardil.

he withdrew, over a long period of time too, and about a year later killed himself. NOTHING -- NOTHING else worked, including ECT, and even rechallenging with MAOIs.

Have you heard of this long-term MAOI poop out, then NOT working when rechallenged happening to otehrs? I wonder what is behind it?

What do you think happens when MAOIs are discontinued in the brain?

 

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