Posted by Bob on July 26, 2011, at 23:13:39
In reply to Re: Study: AD use linked to **MORE** relapses » Bob, posted by SLS on July 21, 2011, at 5:30:58
> > I know through personal experience that, of the available psychotropics, I respond to a treatment regime that must include a combination of two antidepressants - MAOI and TCA.
> > >
> > > - Scott
> >
> >
> > Scott,
> >
> > What is your experience with SSRIs? I've noticed that they're never considered in your current or recent cocktails. Don't the MAOIs cause significant side effects for you, or did you find that the longer you were on them the less pronounced they became?
> >
> > Bob
>
>
> Hi Bob.
>
> I was first exposed to a SSRI in 1983. It was a French drug called Indalpine. I don't know that it is still around, but it also had positive effects on anxiety; though at the cost of moderate amotivation.
>
> The only SSRI drugs that I have not tried are Celexa and Luvox. My history with SSRIs is that I experience a brief 3-day improvement of depression in the first or second weeks. The side effects of SSRIs I experience are fairly typical. but tolerable. Nardil and Parnate both have produced side effects for me that eventually mitigated with time. I *almost* don't know that I am taking them after 4-6 months. I have found this also to be true of some TCAs, even when combined with other antidepressants. Of course, I can only guarantee how these drugs affect me but not everyone else.
>
> Here are the majority of dugs that I have tried over the years to treat bipolar depression. It does not list drug combinations, however. The list would be very long were they included. Not all of the items are antidepressants.
>
>
> - Scott
>
>
> -----------------------------------------------
>
> adinazolam
> agomelatine
> alprazolam
> amitriptyline
> amoxapine
> amphetamine
> aripiprazole
> asenapine
> bromocriptine
> bupropion
> carbamazepine
> chloral hydrate
> chlorpromazine
> clomipramine
> clonazepam
> clorgyline
> desipramine
> doxycycline
> duloxetine
> escitalopram
> fluoxetine
> fluphenazine
> gabapentin
> idazoxan
> iloperidone
> imipramine
> indalpine
> isocarboxezid
> lamotrigine
> levitiracetam
> lithium
> lorazepam
> lurasidone
> methylphenadate
> mifepristone
> milnacipran
> mirtazapine
> moclobemide
> modafinil
> nomifensine
> nortriptyline
> olanzapine
> oxcarbazepine
> paroxetine
> pemoline
> perphanazine
> phenelzine
> PKU-8059
> pregabalin
> protriptyline
> quetiapine
> reboxetine
> risperidone
> selegiline
> sulpiride
> temazepam
> thioridazine
> thyroxine T4
> topiramate
> tranylcypromine
> trazodone
> triazolam
> triiodothyronine T3
> trimipramine
> valproate
> venlafaxine
> viqualine
> ziprasidone
> zaleplon
> zolpidem
> zonisamide
>
>
> ----------------------------------------
>
>
>
> - Scott
I had a plan to try an MAOI that's been on the back burner for a while now. I had mentioned it previously to my pdoc and brought it up again at my most recent appointment. This time though, he seemed to change his tune. I suggested that I hold steady on the nortriptyline I'm on at 80mg, taper down the sertraline from 125mg to zero, wait for 2 weeks and then ramp up on the MAOI. Last time he agreed to consider that, but now he said that it is not feasible because of contraindications between the MAOI and a norepinephrine drug. I had given him an article in support of this a long time ago but now I can't find it. I simply don't think I can survive an excruciating taper, a washout period, a possible failed trial of an MAOI, and then another taper and washout before getting on a drug that may help me. That's a BIG risk for me as I've had 20 years of experience with how I react to withdrawals and washouts... it's not pretty.The other thing that really got me worried about trying an MAOI was that, special diet not withstanding, he said I would not be permitted to take any cold medicines or decongestants while on MAOIs. What happens when someone gets a terrible cold or flu?
What might be the final straw for excluding MAOIs from a trial possibility is the contraindication for taking any triptans while on them. I don't know what I'd do if I got an extreme migraine and couldn't take something like almotriptan. Once I got a headache so serious I had to be hospitalized and receive an injection of high dose Imitrex.
Then there's the serious issue of anasthesia if you need an operation.
I cannot afford to taper on and off of one of these meds for special situations and then spend days or weeks with no meds. It would be life threatening to say the least.
Bob
poster:Bob
thread:991400
URL: http://www.dr-bob.org/babble/20110714/msgs/991979.html