Posted by mtdewcmu on July 16, 2011, at 1:06:32
In reply to Re: Baclofen for sleep?, posted by desolationrower on July 15, 2011, at 20:41:52
>
> i think its worth a shot. i dn't remember reading specifically on improved sleep structure, but i don't remember negative studies either.
>There aren't many studies. Here are a few random ones that I found:
In this one, they gave baclofen to people with mild sleep-disordered breathing and found that they slept longer and got more REM and NREM:
http://www.ersj.org.uk/content/8/2/230.short
Here's one where they gave it to narcoleptic teenagers and found that they slept longer and had more slow wave sleep:
http://www.sciencedirect.com/science/article/pii/S0887899409000824
Here's one where they make reference to GABA-B agonists increasing slow-wave sleep while leaving REM undisturbed.
http://www.ingentaconnect.com/content/adis/cns/2009/00000023/00000008/art00005
Here's one where they found that baclofen helps rats sleep better when they're stressed:
http://www.jstage.jst.go.jp/article/jphs/109/4/109_518/_article
Plus, I have found some studies where they showed that GABA-B is important in sleep architecture.
> diphenhydramine is cheap as shit. 2 or 3 bucks should last you half a year.
>I have already been through the usual suspects.
I have a complex inferiority.
Rx: 40mg citalopram, 30mg d-amphetamine, 15mg mirtazapine, 300mg bupropion
Dx: ADHD (inattentive subtype), depression
poster:mtdewcmu
thread:991101
URL: http://www.dr-bob.org/babble/20110714/msgs/991142.html