Posted by SLS on July 2, 2011, at 0:33:34
In reply to Re: Anti inflammatories and Antibiotics Boost SSRI's » Bob, posted by Phillipa on July 1, 2011, at 23:33:18
> Dentist had me take 3 200mg ibphrophens for 24 hours and honestly the next day felt great. So I believe this could be true. Phillipa
What's old is new again.
I tried doxycycline for over 6 consecutive months as an adjunct to several antidepressants. Nothing. This trial was performed on me at least 5 years ago, and doxycycline was chosen because it is actually a more powerful anti-inflammatory than minocycline.
Is the inflammation present in depression its cause or, rather, is it a systemic reaction to depression? Which is cause and which is effect?
Inflammation does seem to be a biomarker of depression, but how reliable is it in making differential diagnoses or establishing etiologies?
There are numerous dysfunctional microscopic neural structural and chemical changes along with organelle damage that together produce cascades of signalling events that might possibly stimulate an immune reaction to these anomalies. Just a guess. Basically, changes in cell surface proteins and other chemical entities result from the damage, atrophy, and induction of apoptotis of neurons. Much of these signals are also the result of altered gene activity as a reaction to stress and how it works to produce damaging free radical species.
Which came first - the local and systemic biological stresses resulting from depression or the immune processes associated with it?
Poor rats and mice. We may need to sacrifice more of them to figure these things out. It should be easy to design investigations to study a rat's behavioral reaction to pro-inflammatory cytokines.
:-(
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:989944
URL: http://www.dr-bob.org/babble/20110630/msgs/989962.html