Posted by Hombre on June 24, 2011, at 5:37:24
In reply to Re: Stahl's Essential Psychopharmacology, posted by mellow on June 21, 2011, at 3:06:37
Yes, the atypicals kind of work like mirtazapine that way. I take seroquel and mirtazapine on top of Effexor, and that seems to do the trick, perhaps working at "both ends" i.e. reuptake inhibition and increased output of 5HT + NE through the antagonism of the [I forget] receptors.
> Thanks. Covered about 200 pages of it. The atypicals were the most interesting. I had no clue they were using serotonin antagonism to kind of sneak in through the back door and put the breaks on dopamine in the limbic area. Honestly I had no clue there where four separate dopamine pathways. I just always heard people talk about d2 antagonism and how important it was for psychosis reduction. Now I can understand why I got manic when my doc tapered my risperidone. There was less serotonin antagonism on the front end of that dopamine reduction thus I got peppy again.
>
> Great read! A little over my head at some points but I would love to read some more of that stuff.
>
> mellow
poster:Hombre
thread:988912
URL: http://www.dr-bob.org/babble/20110619/msgs/989293.html