Posted by SLS on June 24, 2011, at 5:13:12
In reply to Re: BDNF in depression and fibromyalgia » SLS, posted by hyperfocus on June 23, 2011, at 20:05:13
> The interesting thing is I've found that the effect of amitrip on my day-to-day functioning is best when in the range 150-225mg. Anything higher makes me feel much, much worse.
That is interesting. It's almost like the therapeutic window that exists for nortriptyline. I never understood why nortriptyline should demonstrate this effect and not amitriptyline.
> Fish oil, flaxseed oil or anything with significant Omega-3 also seems to exert this pronounced negative day-to-day negative effect on me.
Fish oil has twice exacerbated my depression within 6 hours of taking my first dose. Strange. A biochemist friend of mine and I both have come to suspect that there is something pharmacological going on here. That some people become manic on fish oil would seem to indicate such. Of course, I really don't know. It's just a hunch. Real scientific, eh?
> I've always suspected that while these drugs and supplements exert their effects on neurogenesis and neuroplasticity, they can actually make our day-to-day symptoms considerably worse. Do you thing this is possible - drugs that do actually repair brain structures but also make us feel much worse? Maybe we should look towards always taking these neurotrophic drugs and trying to combat their adverse effects on our symptoms some other way?
Pretty creative. I wish Zyprexa didn't carry with it such a metabolic liability. It would seem to me to be a good choice to fit your protocol.
Personally, I have never taken a drug that initially exacerbated my depression that later went on to produce an improvement. I was so disappointed when both fish oil and phosphatidylserine made me feel worse. I had thought that combining these two substances with lithium would enhance neuroplasticity and make me feel better.
So much for my personal theories. Maybe it would work for someone else.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:989086
URL: http://www.dr-bob.org/babble/20110619/msgs/989288.html