Posted by larryhoover on June 16, 2011, at 17:02:09
In reply to Re: Inactive ingredients/enteric-coating:do yourself, posted by Lamdage on June 16, 2011, at 16:18:51
> Ok i feel ya. Lets throw neurontin in. Kidding
>
> Seizures dont sound too fun.
>
> I found this on drugs.com
>
> bupropion ↔ phenelzine
> MAJOR INTERACTION
> Applies to: Wellbutrin (bupropion), Nardil (phenelzine)
> CONTRAINDICATED: According to the manufacturer, the acute toxicity of bupropion may be potentiated by coadministration of monoamine oxidase inhibitors (MAOIs). The mechanism of interaction has not been described.
>
> Oh well, i just dont know how to keep my head above water these following couple weeks if im going to have to go a more defensive route. :(I checked four different drug interaction engines, and three gave negative reports, indicating that the severity of the potential interaction was extremely serious. The most detailed report was at DrugDigest.
From Drug Digest:
BUPROPION HYDROCHLORIDE (in Wellbutrin Tablets) may interact with PHENELZINE (in Phenelzine Tablets)
Bupropion has been shown to cause seizures in some people, especially when used in high doses. Although the cause of this potential interaction is not clearly understood, the risk of experiencing a seizure is even greater when bupropion and phenelzine are taken together. Other side effects that can occur with the use of bupropion include agitation, confusion, nausea and vomiting, headaches, and sleep disturbances. Bupropion and phenelzine should not be used at the same time. Wait at least 2 weeks or longer after stopping therapy with phenelzine before starting therapy with bupropion.Ask your healthcare provider about these drugs and this potential interaction as soon as possible.
This interaction is poorly documented and is considered major in severity.
Lar
poster:larryhoover
thread:986279
URL: http://www.dr-bob.org/babble/20110610/msgs/988365.html