Posted by SLS on June 2, 2011, at 20:28:01
In reply to Re: Question for SLS » Christ_empowered, posted by SLS on June 2, 2011, at 16:48:24
Int J Dev Neurosci. 2011 May;29(3):311-24. Epub 2010 Sep 15.
Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia.
Clay HB, Sillivan S, Konradi C.
SourceNeuroscience Graduate Program, Vanderbilt University, Nashville, TN 37232, USA.
AbstractBipolar disorder (BPD) and schizophrenia (SZ) are severe psychiatric illnesses with a combined prevalence of 4%. A disturbance of energy metabolism is frequently observed in these disorders. Several pieces of evidence point to an underlying dysfunction of mitochondria: (i) decreased mitochondrial respiration; (ii) changes in mitochondrial morphology; (iii) increases in mitochondrial DNA (mtDNA) polymorphisms and in levels of mtDNA mutations; (iv) downregulation of nuclear mRNA molecules and proteins involved in mitochondrial respiration; (v) decreased high-energy phosphates and decreased pH in the brain; and (vi) psychotic and affective symptoms, and cognitive decline in mitochondrial disorders. Furthermore, transgenic mice with mutated mitochondrial DNA polymerase show mood disorder-like phenotypes. In this review, we will discuss the genetic and physiological components of mitochondria and the evidence for mitochondrial abnormalities in BPD and SZ. We will furthermore describe the role of mitochondria during brain development and the effect of current drugs for mental illness on mitochondrial function. Understanding the role of mitochondria, both developmentally as well as in the ailing brain, is of critical importance to elucidate pathophysiological mechanisms in psychiatric disorders.
Some see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:986789
URL: http://www.dr-bob.org/babble/20110529/msgs/986977.html