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Re: TDp Journal Article #2 + #3 Bob

Posted by SLS on May 14, 2011, at 5:29:18

In reply to Re: TDp Journal Article #2 + #3 SLS, posted by Bob on May 14, 2011, at 0:11:59

> >
> > Perhaps there is a way to discourage the hypothesized induction of tardive dysphoria using other pharmacological agents. It will be interesting to see if vilazodone (Viibryd), a serotonin reuptake inhibitor and 5-HT1a receptor agonist, possesses a reduced risk of a dysphoric reaction. If 5-HT1a stimulation does not prevent tardive dysphoria, perhaps to attack it from the other angle using pindolol as a 5-HT1a autoreceptor antagonist might work. I need to think about these two opposing effects on neurotransmission more to be able to predict which of the two angles makes more sense.
> >
> >
> > - Scott
> Got a nasty migraine yesterday so I reached for the old trusty Axert (almotriptan). Got curious after I saw this post about drugs that affect serotonin receptor subtypes so I looked up the Axert info and discovered that it is a "potent 5-HT1B/1D serotonin agonist". I guess this class of headache drugs don't have beneficial mood effects or I probably would have heard about it by now.

I'm afraid that I don't know much about those serotonin receptors. Currently, I don't know of any antidepressant that works on them. However, lithium does target the 5-HT1b receptor, and thus modulates the serotonin system.

Linkadge is the best resource for describing the properties of various receptors.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.




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