Posted by linkadge on April 17, 2011, at 16:16:55
In reply to Re: the only way out, posted by poser938 on April 17, 2011, at 14:20:18
>just wanted to comeon this site and maybe find >an anser instead of being told immaking it up in >my head again.
Who said you're making it up???
I believe that what you're experiencing is very real and very painful. But sometimes people come to the wrong conclusions about what exactly is the source of their suffering.
When my uncle was severely depressed, he thought he had committed the unforgivable sin. He felt so sh*tty that this was the only possible explaination his mind could come up with. Did I ever believe he was making it up? No I fully knew that he felt like hell, but I also believed he was misattributing the wrong thing for his suffering.
I know for a fact that medications *can* make certain states worse, but there is no evidence that antidepressants irriversably damamge the brain. This has only been shown with high dose stimulants.
Look the only evidence you are presenting us with here is the fact that you took mirapex and you started feeling worse, and you have been feeling worse since.
Well yes, mirapex could make depression worse, this side effect has been occasonally noted in people with parkinsons. Its not ususal, but not impossible.
Somtimes a drug can put somebody into a bad funk that is hard to get out of. Sometimes drugs can simply push the affective state further into the negative trajectory in which it was headed.
However, unless you have seen your own brain tissue under a microscope, there is no way to conclude that your brain is irriversably damaged.
Depression causes suicide. If you can't see that you're still depressed, than nobody can help you.
Depression causes low BDNF, low BDNF causes low trk-b activation. The reduced trk-b activation reduces P11 expression in the neucleus accumbens. This reduces the surface expression of 5-ht1b receptors in the neucleus accumbens. The reduced 5-ht1b receptors causes a dramatic reduction in the release of dopamine in the NAC. This causes anhedonia.
You need to boost your BDNF levels.
Anhedonia is the ***CORE*** smptom of depression. Plain and simple. Anhedonia lasting more than 2 weeks is sufficiant to diagnose major depressive disorder.
Don't know what you want to hear.
Relavant Studies:Mirapex protects against neurotoxicity to dopamienrgic neurons in the brain
http://www.ncbi.nlm.nih.gov/pubmed/15473989
Mirapex protects against loss of tyrosine hydroxylase from lactacystin toxicity.
http://www.ncbi.nlm.nih.gov/pubmed/18555604
Mirapex induces trophic effects on mesencephalic dopamine neurons.
http://www.ncbi.nlm.nih.gov/pubmed/16307585
Another study shows mirapex's neuroprotective effect similar to potent antioxidants:
http://www.ncbi.nlm.nih.gov/pubmed/10087005
Mirapex protects against l-dopa induced neurotoxicity:
http://www.ncbi.nlm.nih.gov/pubmed/9203083
Another study suggesting the trophic action of mirapex on dopaminergic neurons:
http://www.ncbi.nlm.nih.gov/pubmed/9593863
Go get more effective treatment for your depression.
Linkadge
poster:linkadge
thread:983009
URL: http://www.dr-bob.org/babble/20110406/msgs/983092.html