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Re: relevant diff betw MPH and AMP is the transporter

Posted by linkadge on March 8, 2011, at 15:33:37

In reply to relevant diff betw MPH and AMP is the transporter, posted by iforgotmypassword on March 8, 2011, at 14:38:01

First of all, this is simply one study, and it is by no way conclusive. Like mentioned, the study did not find a unanimous increase in parkinsons in amphetamine users (i.e. no increased incidence was found in those using the drugs for weight loss). I would like to see more studies confirming this finding, and which drugs, at which doses.

>is theorised that this is what causes the >intractable apathy, and blown executive >function, proper inhibition/disinhibition in >those having dealt with sufficient AMP and meth->AMP addiction

There is no evidence that use of amphetamine in theraputic doses causes these problems.


>but that somehow functioning of mesocortical and >mesolimbic pathways go first, rather than what >is assumed in parkinson's where nigrostriatal >pathway degeneration is what's focused on.

Says who?

Also keep in mind, the brain has its own version of amphetamine (PEA). PEA acts identically to amphetamine in terms of transporter reversal and monoamine release. High doses of PEA can cause neurotoxicity and psychosis just like with amphetamines. Obviously there is a theraputic, physiological level of PEA. PEA has been shown (in many studies) to be low in ADHD.

My personal thoughts are that amphetamine also has a window of theraputic effect. The study posted does not really focus on the theraputic use of amphetamines in ADHD. By not specifically studying ADHD, there really is no good control. I.e. in which cases was amphetamine abused vs. used? Also, isn't it possible that an individual with dopamine system dysfunction might be more prone to use amphetamines in the first place?

Some studies show that theraptic use of amphetamines can actually *enhance* motor recovery in stroke. Also, in animal models of ADHD, amphetamines are trophic to dopaminergic pathways in the prefrontal cortex.

I would still be cautious about implicating theraptic use of amphetamines in parkinsons development. I don't really think we have the data to suggest that yet.

Linkadge


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