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Re: Questions On Depression and Nardil » pedr

Posted by Chairman_MAO on February 3, 2011, at 14:31:15

In reply to Re: Questions On Depression and Nardil » luckyduck, posted by pedr on February 3, 2011, at 13:36:45

>For instance, there is no research whatsoever on the body weight 1kg / 1mg ratio. It's a rule-of-thumb that some psychs employ but certainly not all. My (competent) psych had never heard of it.

You are wrong, and so is your doctor--unless you misrepresented what he said, which is possible.

"Clinical response to phenelzine is related to platelet MAO inhibition and dosage per unit body weight."

http://www.ncbi.nlm.nih.gov/pubmed/365127

And that's from 1978! Nothing earth-shattering here.

Yes, it is a heuristic, and clinical response matters most. However, it is based on research: unless you get blood work done and follow platelet MAO, one should titrate to desired effect, which seems to happen around 1mg/kg/day. People with abnormal liver function, etc., need not apply.

I have no medical degree, but I can read and understand concepts.

"No research whatsoever" is a strong statement!


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