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Re: Anorgasmia antidotes » tensor

Posted by SLS on December 10, 2010, at 15:35:04

In reply to Re: Anorgasmia antidotes » SLS, posted by tensor on December 10, 2010, at 6:15:44

> > You could look at buspirone for chronic administration. If it is to work, it should do so before two weeks pass. For acute administration (PRN), you could investigate whether cyproheptadine appeals to you.
> >
> >
> > - Scott
>
>
> Hi Scott!
>
> I'm looking for prn solution, not keen on the idea of chronic administration for a side effect that isn't 'dangerous'. Since I have no problems with my sexual ability now (thanks to mirtazapine) with mirtazapine/escitalopram combo I figure that the anorgasmia on mirtazapine/CMI combo isn't due to increased serotonin levels. Makes sense?
> I have done some research on this topic and the way cyproheptadine is thought to work is through 5HT2-antagonism, which both mirtazapine and clomipramine have plenty of.
> This makes me believe that ACh(m)-blockage is the culprit and that an effective antidote could be bethanechol. What do you think?
>
> /Mattias

I have not heard that an antimuscarinic could be responsible for anorgasmia. There needs to be a balance between 5-HT2c and 5-HT1a receptor activation in order to function sexually. Libido, erections, and orgasm are affected by SSRIs. I believe that, when stimulated, 5-HT2c receptors are responsible for achieving erections. 5-HT1a receptor stimulation is responsible for maintaining libido. Of course, circuits using other neurotransmitters (NE and DA) play a role in facilitating orgasm.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

 

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