Posted by morgan miller on November 9, 2010, at 15:24:53
In reply to Re: One person's argument for Escitalopram, posted by linkadge on November 9, 2010, at 6:14:44
> I have friends who failed every ssri and then respond to something like St. John's Wort.
>
> Tell me this, zoloft is supposedly a "first line treatment" for depression. In head to head trials it performed a little worse than SJW. Why is SJW not a first line depression treatment then?
>
>
> Linkadge
>I agree that SJW should be a first line treatment fro mild to moderate depression, but I'm not sure about major depression. It may help in some cases of major depression, especially at higher than normal doses, but from what I have read and experienced(anecdotal), SJW is not as effective as in treating major depression as pharmaceutical drugs are.
Can you post the links for these trials? I'm interested in reading them. I think we always need to take into account bias and flaws in trials. Just like there may have been these issues with the studies on Lexapro and other big pharma drugs. Were these studies done in Germany where SJW is the first line of treatment for depression? Were these studies funded by the companies that make either Kira or Perika?
I'm also wondering if drop out due to side effects influenced the outcome of these studies. Many people drop out due to side effects. If they stuck with a drug a little longer and they found the right dose, the drug may have ended up being very effective without unbearable side effects. If the side effects were flat out unbearable, I don't blame anyone for dropping out of their trial.
poster:morgan miller
thread:968886
URL: http://www.dr-bob.org/babble/20101107/msgs/969417.html