Posted by hopefullynow on November 6, 2010, at 7:43:55
In reply to Muscle weakness-Clomipramine, posted by Justherself54 on November 2, 2010, at 12:03:14
Justherself, i'm on 75 mg of clomipramine and I know exactly the feeling that you're describing.It seems that clomipramine lowers the muscle tone dramatically.Here, on PB were some that disagreed, but it's hard to tell if you do not train regularly.For me, the weakness begun when i raised the dosage from 50 to 75 mg.I train almost every day and that weakness was so disturbing that i had to choose of stopping clomipramine or quickly find a remedy.Fortunately I found that adding 25-50 mg of Maprotiline (NRI)solved the jelly state in a matter of days.So, I think it's because clomipramine boosts serotonin way much than norepinephrine at least in some individuals, although some say that the metabolite of clomipramine - desmethylclomipramine are way much stronger NRI than the mother drug.
Before discovering Maprotiline i tried Remeron, low dose prozac, wellbutrin.They didn't helped too much.
poster:hopefullynow
thread:968066
URL: http://www.dr-bob.org/babble/20101030/msgs/968761.html