Posted by ed_uk2010 on October 22, 2010, at 16:57:28
In reply to Re: Going from Zoloft to Remeron I am worried :(, posted by linkadge on October 22, 2010, at 14:54:15
>I think I remember reading that the majority of citaloprams sigma agonism is in the r isomer, thus escitalopram would not be as potent a sigma agonist? Also isn't citalopram more potent at 5-ht2c and histamine h1? These properties could produce some theraputic effect.
Since Lexapro is patent-protected but Celexa is off-patent, there are very good reasons for Lundbeck to promote the alleged superiority of Lexapro. The trials presented by Lundbeck suggest that Lexapro is slightly more effective than Celexa and also somewhat better tolerated than other SSRIs. To what extent this is true will only become clear when we see independent evidence. At the moment, the appealing diagrams presented on the Lexapro website are IMO pseudoscience.
My personal experience with Lexapro so far has been positive. I do not know how much of this is due to psychological reasons. I started Lexapro with the attitute that 'it might be better and it certainly shouldn't be worse'... so there could be some placebo effect going on. Many people on babble are quick to assert that such psychological factors do not influence them, particularly with regard to discussion of generics. I think this is very unwise.
poster:ed_uk2010
thread:966136
URL: http://www.dr-bob.org/babble/20101020/msgs/966579.html