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Re: Diphenhydramine contra-indications? » ed_uk2010

Posted by medamorphosis on October 8, 2010, at 14:58:19

In reply to Re: Diphenhydramine contra-indications?, posted by ed_uk2010 on October 8, 2010, at 14:28:56

> Since you're already on a med with sedative antihistamine properties (trimipramine), I doubt that diphenhydramine would help you sleep.
>
> Cyproheptadine (Periactin) is currently out of stock in the UK.

Thanks mate.

Im aware lots of TCAs (and other meds) have a strong antihistamine effect (amitryptyline, mirtazepine, etc). But, theres something about trimipramine wich seems to enhance REM sleep- the dream stage of sleeping. Its very intense and i cant see how this can be put down simply to its antihistamine effect. I believe its something else. Hence why cyproheptadine, despite being a sedating antihistamine shows to reduce nightmares/dreams. Also, I can never recount having dreams or nightmares from taking diphenhydramine itself.
And although nightmares are a possible side effect of amitryptyline, its not renound for them, unlike trimipramine. And ive been on amitryptyline before on its own. No recount of dreams then either. Which is why I intend to switch to it, esp as you say cyproheptadine is out of stock in the UK so thats obviously not an option.

I'll post tomorrow to say if the diphenydramine helped or not. I'll probably need 100mg but I'll start with 50mg.

BTW Ed, I should be getting Marplan again very soon- any minute now so-says my pharmacist. Apparently it went dry because if inpurities in the raw ingredients the drug-makers received prior to the drought. Just what my pharmacist said. Its a good job I stocked up well on it! Still have a bottle left :)


U.K.resedent
Ills: AvPD, major depression, addictive personality
Regime: 90mg isocarboxazid, 4mg clonazepam, 100mg trimipramine, 105mg lofepramine, 2-3g DLPA, hi-dose b vits

 

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