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Re: ZYPREXA withdrawal

Posted by ed_uk2010 on September 11, 2010, at 14:30:31

In reply to ZYPREXA withdrawal, posted by Huxley on September 11, 2010, at 2:21:53

>Is there anything that can help with Zyprexa withdrawal?

They sedating antihistamine promethazine (Phenergan) might help with symptoms such as insomnia, nausea and agitation.


>Is it caused by a cholinergic rebound?

Probably not, or only to a small extent. Olanzapine is only modestly anticholinergic. The withdrawal symptoms occur when all the different subtypes of dopamine and serotonin receptors which were previously blocked by the drug, aren't blocked anymore.

Slow tapering is vital + the use of 'milder' drugs such as promethazine where appropriate.

Best of luck.

 

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URL: http://www.dr-bob.org/babble/20100908/msgs/962082.html