tricyclics + MAOI

Posted by atypical on September 1, 2010, at 7:33:15

In the documentation, virtually all tricyclics are said to be contraindicated with MAOIs. In practice, however, how true is this, since there is great variation in the amount of serotonin reuptake among tricyclics? Or is serotonin not the issue here? I know clomipramine acts a lot on serotonin, while desipramine acts very little on serotonin. Could desipramine, therefore, be used safely with an MAOI?
Atypical

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tricyclics + MAOI atypical 9/1/10
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