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Re: St Johns Wort Combined with SSRI's » sewerrat

Posted by SLS on August 30, 2010, at 5:51:33

In reply to Re: St Johns Wort Combined with SSRI's » morgan miller, posted by sewerrat on August 30, 2010, at 4:26:22

> Yes ,from what i have read of scotts posts, he takes far to many different meds.

According to whose paradigm?

> His choise of course ,just my opinion.He never seems to get much remission on these cocktails only more side effects.

Yup. I guess I should stop looking, right? Where is the logic in that?

> SJW is a MAOI so i hope you have started you new diet to fit in with your abscure choise of meds.

I know that there was great debate about this 10 years ago. Can you produce a recent citation that offers evidence of pharmacologically significant MAO inhibition by SJW?

Thanks.

"Early in vitro studies of various components of St. John's Wort extract led to the establishment of MAO inhibition as the possible mechanism for Hypericum's antidepressant effects. [ 10,11 ] However, more recent investigation in this area suggests that, although MAO inhibition does occur with high concentrations of Hypericum constituents, it does not in the amounts found in commercial extracts."

http://www.chiro.org/nutrition/ABSTRACTS/St_Johns_Wort_Clinical_Effects.shtml

Unfortunately, this is not a citation of the original work. It is a paraphrase. I am still trying to find abstracts on Medline that support MAO inhibition as a property of SJW. All I can find are abstracts that refute this notion.

http://www.ncbi.nlm.nih.gov/pubmed/15536462


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