Posted by linkadge on August 6, 2010, at 13:18:35
In reply to Re: Acetylcholine + Depresion, posted by dragonblack on August 6, 2010, at 13:12:11
Whenever I take something pro-cholinergic, the immediate effect is good, almost euphoric. But then after about an hour there is more of a depressant action.
I've wondered if this was due to the actions of acetycholing on the nicotinergic receptors? Agonism at the nicotine receptors induces dopamine release, but so does antagonism of the acetylcholine m1 receptors. So perhaps a combined nicotinergic agonist + M1 antagonist would have antidepressant like effects.
Nicotine itself isn't an MAOI. Tobacco smoke contains compounds which inhibit MAO.
There is interaction between cannabanoid receptors and acetylcholine receptors, but I don't think that cannabanoid receptors are a subtype of acetylcholine receptor.
Linkadge
poster:linkadge
thread:957470
URL: http://www.dr-bob.org/babble/20100731/msgs/957514.html